Dr. Beverly Davidson is Professor of Pathology and Laboratory Medicine at the University of Pennsylvania and holds the Arthur V. Meigs Chair in Pediatrics at the Children’s Hospital of Philadelphia (CHOP). She also directs the Raymond G Perelman Center for Cellular and Molecular Therapeutics at CHOP. Dr. Davidson’s neurobiology laboratory focuses on understanding the molecular bases of neurodegenerative disorders including lysosomal storage disorders and dominantly inherited diseases such as Huntington’s and the Spinocerebellar ataxias. Her laboratory employs a range of methods from single cell technologies to animal studies to assess novel therapeutic approaches and the molecular bases for neurodegeneration.
In her talk, Dr. Davidson will provide an overview of recent research approaches for inherited disorders that impact CNS function. One emphasis of the data presented will be recent developments in her laboratory, and others, to target biologicals such as gene therapy vectors to particular brain regions, and to regulate the expression of gene therapies once delivered to the brain.